This study evaluates the effects of consuming a defined, plant-based diet on lipoprotein(a) and other atherogenic particles associated with cardiovascular disease risk.
Lipoprotein(a) is a carrier of oxidized low-density lipoprotein and is a particularly atherogenic biomarker. Lp(a) has been previously documented to be resistant to dietary therapies and its concentration is thought to be determined by genes. A plant-based diet has not been previously used in an attempt to influence the concentration of Lp(a). Participants were instructed to follow a defined, plant-based dietary intervention for four weeks. All animal products were excluded. Cooked foods, free oils, soda, alcohol, and coffee were also to be excluded. All meals and snacks were provided to the participants for the full duration of the intervention. Emphasized were raw fruits and vegetables, while seeds, avocado, raw oats, raw buckwheat, and dehydrated foods were prepared as condiments. Vitamin, herbal, and mineral supplements were to be discontinued unless otherwise clinically indicated. Participants were not advised to alter their exercise habits. Serum biomarkers were obtained from participants at baseline and after 4-weeks.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
33
Subjects consumed a defined, plant-based diet for 4-weeks. Emphasized were raw fruits and vegetables.
Montgomery Heart & Wellness
Houston, Texas, United States
Change in serum lipoprotein(a)
Serum Lp(a) (nmol/L) was documented at baseline and after 4-weeks
Time frame: Baseline and 4-weeks
Change in serum total cholesterol
Serum total cholesterol (mg/dL) was documented at baseline and after 4-weeks
Time frame: Baseline and 4-weeks
Change in serum low-density lipoprotein cholesterol
LDL cholesterol (mg/dL) was documented at baseline and after 4-weeks
Time frame: Baseline and 4-weeks
Change in serum high-density lipoprotein cholesterol
Serum HDL (mg/dL) was documented at baseline and after 4-weeks
Time frame: Baseline and 4-weeks
Change in serum apolipoprotein-B
Serum Apo-B (mg/dL) was documented at baseline and after 4-weeks
Time frame: Baseline and 4-weeks
Change in serum low-density lipoprotein particles
Serum LDL-P (nmol/L) was documented at baseline and after 4-weeks
Time frame: Baseline and 4-weeks
Change in serum small-dense low-density lipoprotein cholesterol
Serum sdLDL-C (mg/dL) was documented at baseline and after 4-weeks
Time frame: Baseline and 4-weeks
Change in serum high-density lipoprotein 2 cholesterol
Serum HDL2-C (mg/dL) was documented at baseline and after 4-weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Time frame: Baseline and 4-weeks
Change in serum apolipoprotein A-1
Serum Apo A-1 (mg/dL) was documented at baseline and after 4-weeks
Time frame: Baseline and 4-weeks