In this randomized, double-blind, placebo controlled project, the investigators would like to assess the effect of a specific light, as compared to placebo light, on wakefulness (circadian rhythms, homeostasy, sleep-wake cycle), awareness (perceptual and self consciousness), cognition (attention, memory) and underlying brain activity (electrophysiology and neuroimaging)
The investigators will use behavioral (CRS-R, CAP, actimeter, brainstem reflexes), physiological (body core temperature, saliva, urine, heart rate, blood sample), neuroimaging and neurophysiological tools (PET, fMRI, TMS-EEG, resting-state and auditory paradigm EEG) before, during and after treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
50
Active light will be used for one week, as compared to placebo light.
Placebo light will be used for one week, as compared to real light exposition.
Changes in the Coma Recovery Scale-Revised scores.
Identify the improvement in sleep-wake cycle and circadian rhythm after the real light therapy exposure, with behavioral analyses and diagnosis through the CRS-R results.
Time frame: 4 weeks study
Change in sleep-wake cycles through the Nociception Coma Scale-Revised, after the exposition of real light instead of placebo light.
Identify the improvement in sleep-wake cycle and circadian rhythm after the real light therapy exposure, with behavioral analyses through the NCS-R results.
Time frame: 4 weeks study
Change in sleep-wake cycles through the actimetry, after the exposition of real light instead of placebo light.
Identify the improvement in sleep-wake cycle and circadian rhythm after the real light therapy exposure, with behavioral analyses through the arms movements measured with the actimetry.
Time frame: 4 weeks study
Change in sleep-wake cycles through the brain metabolism with Positron Emission Tomography, after the exposition of real light instead of placebo light.
Identify the improvement in sleep-wake cycle and circadian rhythm after the real light therapy exposure, with PET scan analyses.
Time frame: 4 weeks study
Change in sleep-wake cycles through the hemodynamic function of the brain with functional Magnetic Resonance Imaging, after the exposition of real light instead of placebo light.
Identify the improvement in sleep-wake cycle and circadian rhythm after the real light therapy exposure, with fMRI analyses.
Time frame: 4 weeks study
Change in sleep-wake cycles through the electrical activity of the brain with electroencephalography, after the exposition of real light instead of placebo light.
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Identify the improvement in sleep-wake cycle and circadian rhythm after the real light therapy exposure, with EEG analyses.
Time frame: 4 weeks study
Change in sleep-wake cycles through analyses of melatonine hormone, after the exposition of real light instead of placebo light.
Identify the improvement in sleep-wake cycle and circadian rhythm after the real light therapy exposure, with urine analyses.
Time frame: 4 weeks study
Change in sleep-wake cycles through temperature measurements, after the exposition of real light instead of placebo light.
Identify the improvement in sleep-wake cycle and circadian rhythm after the real light therapy exposure, with body core temperature analyses.
Time frame: 4 weeks study
Change in the outcomes by the assessment of the Glasgow Outcome Scale Extended, after the study.
Improvement of the recovery's outcomes after the end of the real light therapy exposure.
Time frame: 2 years after