The objective of this common multicenter protocol is to test the hypothesis that algorithmic tools using clinical Neonatal Intensive Care Unit (NICU) cardiorespiratory monitoring data can detect ventilatory control instability and predict chronic and acute respiratory consequences of ventilatory control instability and autonomic dysregulation.
Study Type
OBSERVATIONAL
Enrollment
739
University of Virginia
Charlottesville, Virginia, United States
Clinical Outcome
"Favorable": Either (1) an inpatient at 40 weeks post-menstrual age and not on oxygen, nor on other flow/pressure respiratory support, nor on inhaled/oral/IV respiratory medications, OR (2) discharged prior to 40 weeks post-menstrual age not on respiratory meds, oxygen, or other respiratory support. "Unfavorable": Either (1) Deceased at 40 weeks , (2) inpatient on meds/O2/support at 40 weeks post-menstrual age, or (3) previously discharged prior to 40 weeks on meds/O2/support
Time frame: 40 weeks post-menstrual age.
Physiological Outcome
Reported Value will be the percentile value of scores, as plotted on a standard curve of scores for peers. The score is calculated by aggregating the following measurements: 1. Periodic Breathing Percentage (%) 2. Number of Apnea events (#) 3. Number of Bradycardia events (#) 4. Number of Desaturation events (#) 5. Number of combined events (example Apnea with Bradycardia and Desaturation (#)
Time frame: 36 weeks and 1 day to 37 weeks and 0 days, post-menstrual age
time on respiratory support and medications
Time frame: before 52 weeks post-menstrual age
chronic lung disease
Time frame: before 52 weeks post-menstrual age
pulmonary hypertension
Time frame: before 52 weeks post-menstrual age
sepsis
Time frame: before 52 weeks post-menstrual age
necrotizing enterocolitis
Time frame: before 52 weeks post-menstrual age
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