The investigator will evaluate the influence of lung protective ventilation on postoperative clinical outcome in patients undergoing one-lung ventilation for pulmonary lobectomy.
The hypothesis is that application of low tidal volume, moderate inspired oxygen fraction (FiO2) ,intermittent alveolar recruitment and positive end-expiratory pressure (PEEP) would be more beneficial than conventional ventilation in patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
120
High tidal volume, moderate inspired oygen fraction (FiO2).
High tidal volume, high inspired oygen fraction (FiO2).
Low tidal volume, PEEP, moderate inspired oygen fraction (FiO2) and recruitment maneuver.
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu, China
RECRUITINGThe proportion of patients with pulmonary complication
The number of patients with pulmonary complication including atelectasis, pulmonary infiltration, pulmonary edema, pulmonary infection, pleural effusion and pulmonary embolism.
Time frame: up to postoperative 3days
PaO2 /FiO2
Time frame: 10 min after induction, 30 and 60 min after start of one-lung ventilation, 15 min after restart of two-lung ventilation, 1 hour after the end of surgery
respiratory compliance
Dynamic compliance, Static compliance
Time frame: 10 min after induction, 30 and 60 min after start of one-lung ventilation, 15 min after restart of two-lung ventilation
IL6
Time frame: 10 min after induction, 60 min after start of one-lung ventilation, 15 min after restart of two-lung ventilation
IL10
Time frame: 10 min after induction, 60 min after start of one-lung ventilation, 15 min after restart of two-lung ventilation
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Low tidal volume, PEEP, High inspired oygen fraction (FiO2) and recruitment maneuver.