Identify 18-Fluorodeoxyglucose (18F-FDG) positron emission tomography-computed tomography (PET-CT) parameters predictive of tumor response and local control
The identification of robust prognostic and predictive markers could allow the individualization of pulmonary stereotactic radiotherapy treatments and the selection of patients at high risk of relapse, who could then benefit from a dose escalation in order to increase the chances of local control . Beyond the pulmonary RTS (Radiotherapy in stereotactic condition), this study will aim to generate one or more models of multi-scale response to hypofractionated irradiation from biomarkers (biological or images) extracted from preclinical or clinical literature data and to allow simulations of Various modified fractionation irradiation schemes, potentially leading to new regimens that reduce side effects and increase therapeutic efficacy.
Study Type
OBSERVATIONAL
Enrollment
60
The patient will have an initial pre-therapeutic assessment in the 8 weeks before the start of radiotherapy Then, radiation therapy planning with 3 free breathing 4D (4 dimensions) scanners performed over 8 days without injection of iodinated contrast agent. Then the patient will receive his treatment by conventional stereotactic radiotherapy
CHRU de Brest
Brest, France
RECRUITINGCentre Eugène Marquis
Rennes, France
RECRUITINGInstitut de Cancérologie de l'Ouest
Saint-Herblain, France
RECRUITINGKinetics of PET-CT parameters : standardized uptake value (SUV) max
SUV max will be measured before and after stereotactic irradiation.
Time frame: 2 years
Tumor metabolic response
Tumor metabolic response, as assessed on 18F-FDG PET-CT at 6 months of end of radiotherapy
Time frame: 2 years
Local control
Local control defined by the absence of progression in the irradiated area
Time frame: 2 years
Kinetics of PET-CT parameters : metabolic tumor volume
Metabolic tumor volume (MTV) will be measured before and after stereotactic irradiation.
Time frame: 2 years
Kinetics of PET-CT parameters : texture parameters :quantitative extraction of images by specific software
The first-order form parameters and statistical parameters, the second order (based on the matrix of co-occurrence of the grey levels and the matrix of differences of grey levels) and of the third order (based on the matrices of alignment of the grey levels and the matrices of sizes of zones) will be studied.
Time frame: 2 years
Kinetics of serum markers
The kinectic will be measured
Time frame: 2 years
Predictive power of serum markers for tumor response and local control
This predictive power will be measured
Time frame: 2 years
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Clinique d'Oncologie et Radiothérapie
Tours, France
COMPLETEDPredictive power of metabolic imaging parameters for tumor response and local control Predictive power of metabolic imaging parameters for tumor response and local control
This predictive power will be measured
Time frame: 2 years
Correlation between these parameters
The correlation will be measured
Time frame: 2 years
Survival in disease
The survival in desease will be observed
Time frame: 2 years
Survival without metastasis at a distance
The survival without metastasis will be observed
Time frame: 2 years
Radiation-induced toxicity
The radiation-induced toxicity will be observed
Time frame: 2 years