This study evaluates whether some patients with nasopharyngeal carcinoma but with low risk of distant metastasis can be treated with only radiotherapy and concomitant chemotherapy but without additional adjuvant chemotherapy.
The standard treatment for stage II-III nasopharyngeal carcinoma is radiotherapy with concomitant chemotherapy and adjuvant chemotherapy. A subset of these patients has very low risk for distant metastasis that adjuvant chemotherapy is probably unnecessary. The investigators would like to know if same therapeutic effect and survival rate can be achieved without adjuvant chemotherapy, (i.e. less chemotherapy, same effect)
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
263
External beam radiotherapy with curative intent, at least 66 Gy
cisplatin IV injection over 3 hours
5-FU IV 24 hours continuous infusion
Distant-metastasis-free survival
percentage of patients who survived and has no distant metastasis
Time frame: 5 years
overall survival
percentage of patients who survived
Time frame: 5 years
disease-free survival
percentage of patients who survived and had no disease recurrence
Time frame: 5 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.