Drug Patch Tests in Patients With Severe Cutaneous Adverse Reaction to Drugs (SCARs)

Chulalongkorn University30 enrolled

Overview

The study is about drug patch tests in patients who have history of severe cutaneous drug reaction including Steven Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), Drug-induced eosinophilia and systemic symptoms (DRESS), AGEP (Acute generalized exanthematous pustulosis) and generalized bullous fixed drug eruptions. This study also investigate in Enzyme-linked immunosorbent spot assay (ELIspot) and lymphocyte transformation test. We also trying to prove the correlation among result of drug patch tests, ELIspot and LTT.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Drug Reaction

Interventions

patch testOTHER

Patch test allergen from chemotechnique diagnostics, pure drug and drug as is combine with petrolatum or aqueous.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with history of Steven Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), drug-induced eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), generalized bullous fixed drug eruption in the past 24 months. * Age more than 18 years old Exclusion Criteria: * Receiving immunosuppressive drugs or more than 10 mg/day of prednisolone within 1 month. * Pregnancy and lactation

Locations (1)

Division of Dermatology, Faculty of Medicine, Chulalongkorn University

Bangkok, Thailand

RECRUITING

Outcomes

Primary Outcomes

Prevalence of positive drug patch test results.

Time frame: 3 years

Secondary Outcomes

correlation of drug patch test results, ELIspot and lymphocyte transformation test.

Time frame: 3 years

Data from ClinicalTrials.gov

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