Post Static Cold Storage Normothermic Machine Liver Perfusion

Peak serum AST (U/L)

The highest AST level recorded in the first 7 days post-transplant will be identified. This is a surrogate marker for longer-term outcome. It will be compared with matched controls of livers undergoing continuous NMP and SCS

Time frame: 7 days

Early allograft dysfunction (EAD)

This is a composite score which is used to predict longer-term outcome. It comprises: bilirubin \>or=10mg/dL on day 7 post-transplant, international normalized ratio \>or=1.6 on day 7 post-transplant, and alanine or aspartate aminotransferases \>2000 IU/L within the first 7 days post-transplant. This will be compared with matched controls of livers undergoing continuous NMP and SCS

Time frame: 7 days

Primary non-function

This is irreversible graft dysfunction requiring emergency liver replacement during the first 10 days after liver transplantation, in the absence of technical or immunological causes. This will be compared with matched controls of livers undergoing continuous NMP and SCS

Time frame: 10 days

Adverse events, transplantation and organ discard rates.

This composite outcome aims to establish safety and feasibility as well as organ utilisation. It will be compared with matched controls of livers undergoing continuous NMP and SCS

Time frame: 30 days

Biliary investigation or intervention

In order to capture the incidence of ischaemic cholangiopathy, any biliary investigation (such as magnetic resonance imaging) or intervention (such as endoscopic retrograde cholangiopancreatography) will be recorded and compared with matched controls of livers undergoing continuous NMP and SCS