The Effect of Manipulation of the Cervical Spine on Pain Biomarkers

Loma Linda University28 enrolled

Overview

This study evaluates the effect of high-velocity low-amplitude thrust (HVLAT) manipulation to the cervical spine on neuropeptide expression as determined by the plasma concentration of oxytocin, neurotensin, orexin A and cortisol; and Examine the effect of HVLAT manipulation on pain perception in symptomatic females with non-specific mechanical cervical spine pain

A high-velocity low-amplitude thrust (HVLAT) manipulation or commonly known as a spinal manipulation, is an intervention frequently used by physical therapists and other healthcare practitioners as an alternative treatment to help relieve spinal pain The mechanism by which HVLAT manipulation modulates pain remains undefined, although this does not contradict the clinical effects from HVLAT manipulation. Furthermore, there is evidence that suggests analgesia after HVLAT manipulation. There is a variety of observed and proposed phenomena that can explain the mechanisms for the psychological, mechanical, or neurophysiological responses from a HVLAT manipulation associated with alterations in pain processing or sympathetic and motor systems' excitation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Neck Pain, Posterior

Interventions

HVLAT manipulationPROCEDURE

HVLAT will be performed 10 minutes after the first blood draw.

Sham HVLAT manipulationPROCEDURE

Sham HVLAT will be performed 10 minutes after the first blood draw.

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 20 - 45 years of age * A score of 10 or more out of 50 on the Neck Disability Index (NDI) questionnaire * Symptoms of pain present for 30 days or less and no pain symptoms below your shoulder Exclusion Criteria: * Serious condition (such as cancer, spondylolisthesis, rheumatoid arthritis, or ankylosing spondylitis) * Cervical spinal stenosis signs (such as incoordination in hands, arms and legs, inability of walking at a brisk pace, or bowel and bladder incontinence) * Nerve root compression (such as changes in sensation, muscle weakness, or decreased reflexes) * Works the night shift * Steroid medication within 3 months * Pregnancy or postpartum * Pending legal action regarding their neck pain * History of whiplash associated disorder and/or cervical spine surgery

Locations (1)

Loma Linda University

Loma Linda, California, United States

Outcomes

Primary Outcomes

Plasma Concentration of Oxytocin

Samples were analyzed for Human Oxytocin, using the Multiplex Luminex-100 platform (Luminex, Inc., USA).

Time frame: Blood will be drawn 10 minutes prior to HVLAT procedure.

Plasma Concentration of Oxytocin

Samples were analyzed for Human Oxytocin, using the Multiplex Luminex-100 platform (Luminex, Inc., USA).

Time frame: Blood will be drawn immediately after HVLAT procedure.

Secondary Outcomes

Plasma Concentration of Neurotensin

Samples were analyzed for Human Neurotensin, using the Multiplex Luminex-100 platform (Luminex, Inc., USA).

Time frame: Within 10 minutes after consent signature completion

Plasma Concentration of Neurotensin

Samples were analyzed for Human Neurotensin, using the Multiplex Luminex-100 platform (Luminex, Inc., USA).

Time frame: Blood will be drawn immediately after HVLAT procedure.

Plasma Concentration of Orexin A

Samples were analyzed for Human Orexin A, using the Multiplex Luminex-100 platform (Luminex, Inc., USA).

Time frame: Within 10 minutes after consent signature completion

Plasma Concentration of Orexin A

Samples were analyzed for Human Orexin A, using the Multiplex Luminex-100 platform (Luminex, Inc., USA).

Time frame: Blood will be drawn immediately after HVLAT procedure.

Plasma Concentration of Cortisol

Samples were analyzed for Human Cortisol, using the Multiplex Luminex-100 platform (Luminex, Inc., USA).

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.