Assessment of Dried Blood Spot Thyroglobulin and Urinary Iodine Concentration in Pregnant Women

Swiss Federal Institute of Technology2,900 enrolled

Overview

To avoid iodine deficiency and its consequences in pregnant women and their offspring, women should reach a sufficient iodine intake long before conception. To monitor iodine status, median urinary iodine concentration (UIC) is widely used in pregnant women (PW). Thyroglobulin (Tg) us another marker used to assess iodine status . In this study, urine samples as well as dried blood spots will be collected to measure UIC and Tg (as well as other hormones to define thyroid function) in PW. The results shall be used to reassess the threshold which defines iodine status in PW according to UIC.

Study Type

OBSERVATIONAL

Enrollment

2,900

Conditions

Iodine Deficiency Pregnancy Related

Interventions

no interventionOTHER

this is a completely observational study, NO INTERVENTION

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: 1. Generally healthy 2. No major medical illness, no thyroid disease, and taking no chronic medication 3. No use of iodine containing dietary supplements 4. No use of iodine-containing X-ray /CT contrast agent or iodine containing medication within the last year 5. Aged between 18 and 44 at enrollment 6. Singleton pregnancy 7. Non-smoking 8. Residence at study site since 12 months or longer

Outcomes

Primary Outcomes

Urinary iodine concentration and Thyroglobulin concentration in pregnant women.

Analysis of urine and blood samples to find urinary iodine concentration and Thyroglobulin concentration of each participant.

Time frame: June 2018