Safety and Efficacy of Heparin Dosing Score Protocol for Polymyxin-B Hemoperfusion

National Taiwan University Hospital30 enrolled

Overview

Polymyxin B hemoperfusion (PMX-HP) is mainly used to remove endotoxins in septic shock patients with intra-abdominal infections. Because of the concerns of postoperative bleeding, physicians may hesitate to use anticoagulation in patients with septic shock within a few hours after an abdominal operation. We developed a heparin dosing score protocol for heparin dosage adjustment. The purpose of the study is to examine the safety and efficacy of the heparin dosing score protocol.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Septic Shock Polymyxin B Hemoperfusion

Eligibility

Sex: ALLMin age: 20 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * intra-abdominal septic shock patients or documented Gram-negative bacterial septic shock patients who received polymyxin-B hemoperfusion in National Taiwan University Hospital during October 2013-December 2016 Exclusion Criteria: * pregnant woman * patients with do-not-resuscitate declaration * uncontrolled bleeding within 24hr

Locations (1)

Department of Anesthesiology, NTUH, Taipei, Taiwan

Taipei, Taiwan

RECRUITING

Outcomes

Primary Outcomes

premature cartridge clotting rate

the incidence of premature cartridge clotting within 2hr

Time frame: 2 hours

Secondary Outcomes

bleeding event rate

the incidence of substantial bleeding event within 24hr

Time frame: 24 hours

Central Contacts

Chen-Tse Lee, MD

CONTACT

+886972653169 lctbrian314@gmail.com

Data from ClinicalTrials.gov

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