Impact of HMGB1 on Diastolic Dysfunction in Hypertensive Patients

Jing Li100 enrolled

Overview

This study evaluated the association between HMGB1 and diastolic dysfunction in hypertensive patients. HMGB1 level were tested in all patients, and diastolic function determined by echocardiographic.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Diastolic Dysfunction Hypertension Inflammation

Eligibility

Sex: ALLMin age: 30 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: All of the hypertensive patients in both diastolic dysfunction and control groups were either newly diagnosed or were aware of hypertension without using any pharmacotherapy. \- Exclusion Criteria: Individuals already under treatment for hypertension were not include. \-

Outcomes

Primary Outcomes

Differences of HMGB1 levels between hypertensive patients with and without diastolic dysfunction

Blood samples of all individuals are collected on the day of admission and HMGB1 levels are tested. Echocardiographic assessment is performed with echocardiography device by using 2.5-3.5 Mega Hertz(MHz) transducer in the lateral decubitis position.

Time frame: on the day of admission

Secondary Outcomes

Differences of HMGB1 levels between grades of diastolic dysfunction

Time frame: on the day of admission

Data from ClinicalTrials.gov

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