The investigators will be studying the effect of melatonin on blood pressure, insulin resistance, and platelets, along with possible reasons for how melatonin cases these effects.
The investigators will be studying the effect of melatonin on blood pressure and insulin resistance, and possible reasons for how melatonin works on blood pressure and IR. Along with blood testing to measure adipokines, insulin resistance (IR), and platelet function (how well your blood clots), 24-hour ambulatory blood pressure monitoring (ABPM) will be used to measure blood pressure, since ABPM is the gold standard (best method) for accurate assessment of blood pressure status and associated cardiovascular risk. Vascular (blood vessel) function, IR, adipokine levels and sleep quality will also be measured. All study endpoints will be measured at baseline and following 6 weeks of daily melatonin 9 mg dosing.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
31
controlled release, 9 mg taken 30 minutes before bedtime x 6 weeks
Thomas Jefferson University
Philadelphia, Pennsylvania, United States
Office Systolic Blood pressure change
Change in Systolic blood pressure measured in the office at 6 weeks
Time frame: Baseline to 6 weeks
Office Diastolic Blood pressure change
Change in Diastolic blood pressure measured in the office at 6 weeks
Time frame: Baseline to 6 weeks
Ambulatory Systolic Blood pressure change
Change in 24 hour average Systolic blood pressure at 6 weeks
Time frame: Baseline to 6 weeks
Ambulatory Diastolic Blood pressure change
Change in 24 hour average Diastolic blood pressure at 6 weeks
Time frame: Baseline to 6 weeks
HOMA: Homeostasis Model Assessment change
Insulin sensitivity measure change at 6 weeks
Time frame: Baseline to 6 weeks
QUICKI: Quantitative insulin sensitivity check index change
Insulin sensitivity measure change at 6 weeks
Time frame: Baseline to 6 weeks
Arachidonic acid stimulated aggregation change
Platelet activity measure change at 6 weeks
Time frame: Baseline to 6 weeks
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