Transition to Propofol After Sevoflurane Anaesthesia to Prevent Emergence Agitation

Assiut University70 enrolled

Overview

The aim of this randomized double-blinded study is to determine whether transition to propofol for 3 min at the end of sevoﬂurane anaesthesia reduces the incidence of EA in children undergoing genito-urinary paediatric surgeries.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Emergence Agitation

Interventions

PropofolDRUG

propofol 1 mg/kg IV bolus will be given to the patient with a further 2 mg/kg administered manually over the next 3 min prior to the patient leaving the OR

Normal salineDRUG

Normal saline will be administered manually over the next 3 min prior to the patient leaving the OR

Eligibility

Sex: ALLMin age: 3 YearsMax age: 8 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Children Aged 3 - 8 years 2. ASA (I - II) 3. Genito-urinary Surgeries: hernia, varicocele, etc. Exclusion Criteria: 1. Patients or parental refusal 2. Allergy to Propofol or egg products; or a family history of malignant hyperthermia 3. Operating time more than 60 minutes 4. Performance of any other procedure under the same anaesthetic 5. Presence of co-morbidities or congenital anomalies 6. mental disease, neurologic disease, treatment with sedatives, full stomach, or indication for rapid sequence induction.

Locations (1)

Assiut University hospital

Asyut, Asyut Governorate, Egypt

Outcomes

Primary Outcomes

Emergence Agitation

The incidence of EA according to the Watcha scale (deﬁned as a score ≥3 at any time in the 30 min after emergence)

Time frame: 30 min after emergence

Emergence Agitation

The incidence of EA according to the Paediatric Emergence Anaesthesia Delirium (PAED) scale (deﬁned as a score \>12 at any time in the 30 min after emergence )

Time frame: 30 min after emergence

Data from ClinicalTrials.gov

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