Targin® for Chronic Pain Management in Patients With Spinal Cord Injury

The inclusion criteria include, but are not limited to, the following: * Male or female, 18 - 65 years of age * 3 months or more following spinal cord injury * Chronic pain for more than 3 months * AIS score A, B, C, D with any neurological level of impairment. * Must be taking regular opioid medication prescribed by their physician for a minimum 3 months prior to enrollment in the study * Willing and able to comply with all clinic visits and study-related procedures * Able to understand and complete study-related questionnaires * Must provide informed consent The exclusion criteria include, but are not limited to, the following: * A daily dose of MME in excess of the maximum 120 MME (control release) or equivalent to the maximum daily dose of Targin per current Investigator Brochure or Product Monograph (80mg oxycodone hydrochloride and 40mg naloxone hydrochloride) * Presence of severe acute medical issue that in the investigator's judgement would adversely affect the patient's participation in the study * Imminent plan by the medical team to wean or discontinue opioid medication for pain management * Moderate and severe forms of renal dysfunction * Clinically significant abnormal laboratory tests as judged by the investigators. * Hypersensitivity or allergy to opioid medication and/or naloxone. * Use of any medication or treatment that in the opinion of the investigator indicates that it is not in the best interest of the patient to participate in this study. * Major depression as indicated by a PHQ-9 score greater than 15 at baseline, or at the discretion of the investigator. * Cognitive impairment as indicated by a MoCA score less than 26, or at the discretion of the investigator. * Patient is a member of the investigational team or his/her immediate family. * Patient does not have a good command of the English language. * Female patients who are breast-feeding or pregnant. * Individuals with documented substance abuse disorder * Individuals within 1-3 months post-acute surgical intervention requiring opioid therapy