The investigators set out to develop a clinical trial in order to test the topical use of hydrocortisone as a intraoperative irrigant solution. As this route of administration as well as being low cost and not add new steps to the surgical procedure, can contribute to an improved quality of life in the postoperative period of patients undergoing extraction of third molars.
Third molars are the teeth with a higher prevalence of failure in eruption and surgery for extraction of these impacted teeth is one of the most commonly procedures performed by the oral and maxillofacial surgeon. In most cases these are not traumatic procedures, however factors such as patient age, habits, degree of tooth impaction and surgeon experience can influence the surgical trauma and therefore the postoperative period could include swelling and pain of varying magnitudes which can significantly affect the patient's quality of life. The study is designed as a prospective, randomized, placebo-controlled, split-mouth crossover trial. All the patients will be informed of the experimental methodology and signed a institutionally approved consent form. The study is been conducted in compliance with Declaration of Helsinki (1989), and was revised by the Institutional Ethical Committee (protocol 1.167.908).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
40
During the third molar extraction the hydrocortisone solution will be used in the test group
During the third molar extraction the saline solution will be used in the control group
Vitor Pereira Rodrigues
São Paulo, São Paulo, Brazil
Edema
Change in edema measures
Time frame: From the preoperative moment to the second postoperative day
Pain
Quantitative evaluation (amount of analgesic medication intake)
Time frame: Up to 2 days (amount of analgesic medication intake form the immediate postoperative moment to the second postoperative day)
Pain
Subjective evaluation - Visual Analog Scale
Time frame: Up to 2 days (from the immediate postoperative moment to the second postoperative day)
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