Safety and Efficiency of IRE Plus γδ T Cell Against Locally Advanced Pancreatic Cancer

Inclusion Criteria: 1. age: \>18 years 2. participants older than 18 years with either LAPC according to the American Joint Committee on Cancer (AJCC) criteria or isolated local recurrence with a maximum tumor diameter of 5 cm were considered eligible after pathologic confirmation 3. will receive IRE, gd Tcells 4. life expectancy: more than 3 months 5. ability to understand the study protocol and a willingness to sign a written informed consent document 6. adequate liver and renal function were required 7. intolerant or refused to chemotherapy or to chemotherapy Exclusion Criteria: 1. patients with other kinds of cancer 2. history of coagulation disorders or anemia 3. heart disease and diabetes 4. history of epilepsy, severe coronary disease, a history of level 3 hypertension，myelosuppression, autoimmune disease 5. a performance status score of \>2