The Study of Heart Failure With Human Umbilical Cord Mesenchymal Stem Cells (19#iSCLife®-HF)

Inclusion Criteria: * volunteer to participate in clinical trial, and sign informed consent form * with cardiac failure symptoms, including oppression in chest, breathe hard, lower limb edema. And new york heart association class as two to four * heart color ultrasound indicate left ventricular ejection fraction (LVEF) \< 40% * content of serum NT-proBNP \> 450pg/ml Exclusion Criteria: * with severe drug allergy history or allergic constitution * patients were severe infected * with malignant tumor or with high tumor marker * with severe cardiorespiratory dysfunction, hematological system disease * with severe mental disorder, cognitive impairment * with persistent atrial fibrillation, valvular heart disease, dilated cardiomyopathy, hypertrophic cardiomyopathy or restrictive cardiomyopathy patients * end-stage renal insufficiency, pregnancy, or breast feeding women * bleeding tendency, active gastrointestinal ulcer * recent have major surgery, stroke, cancer, hepatic function insufficiency or other life-threatening condition. * under other therapy that possibly influence MSC security or efficacy * donor: HIV, active hepatitis B/C infection, Syphilitic antibody positive * participant/donor: alcoholism, drug addicted, mental disease