Ibuprofen Bioavailability Study

Inclusion Criteria: 1. Male or female subjects who have given written informed consent. 2. Age: ≥ 18 years ≤ 50 years. 3. Body Mass Index (BMI) of ≥ 18.0 and ≤ 30 kg/m2. 4. Healthy as determined by past medical history, physical examination, vital signs, electrocardiogram (ECG), and laboratory tests at screening. 5. Female subject of child bearing potential with a negative pregnancy test at the screening visit and willing to use an effective method of contraception unless of non-childbearing potential or where abstaining from sexual intercourse in line with the preferred and usual lifestyle of the subject from first dose until 3 months after the final dose of study medication. 6. Female subject of non-child bearing potential with negative pregnancy test at the screening visit. 7. Male subject willing to use an effective method of contraception unless anatomically sterile or where abstaining from sexual intercourse in line with the preferred and usual lifestyle of the subject from first dose until 3 months after the final dose of study medication. Exclusion Criteria: 1. Pregnant or lactating females. 2. A history and/or presence of significant disease of any body system, including significant psychiatric disorders, parasuicide. 3. Any condition that may currently interfere with the absorption, distribution, metabolism or excretion of drugs. 4. A history of allergy or intolerance related to treatment with ibuprofen, aspirin or other non-steriodal anti-inflammatory drugs (NSAIDs), or the excipients of the formulations 5. A history of or active peptic or duodenal ulcers or gastrointestinal bleed or upper gastro-intestinal bleed, or other significant gastro-intestinal disorders. 6. A history of frequent dyspepsia, e.g. heartburn or indigestion. 7. A history of significant and frequent migraine. 8. Current smokers or ex-smokers who have smoked or used nicotine replacement products during the 6 months prior to the first dose of study medication. 9. A history of substance abuse (including alcohol). 10. Consumption of foods or beverages containing caffeine (e.g. coffee, tea, cola and chocolate) above 300 mg caffeine per day, prior to 48 hours of each treatment period. (One cup of coffee equals approximately 50 mg caffeine). 11. Those with positive test for drugs of abuse and alcohol. 12. Ingestion of a prescribed drug at any time in the 14 days before the first dose of study medication (excluding hormonal contraceptives and hormone replacement therapy), or consumption of enzyme inhibitors or inducers 30 days prior to the first dose of study medication (such as barbiturates, carbamazepine, erythromycin, phenytoin, etc.). 13. Ingestion of an over-the-counter preparation within 7 days before the first dose of study medication, including herbal medications, vitamins, fish oil supplements, ibuprofen and other NSAIDs. 14. Those who have consumed grapefruit or grapefruit juice, pumelo or Seville oranges in the 7 days before the first dose of study medication. 15. Donation of blood \> 400 mL e.g. to the blood transfusion service in the 12 weeks prior to the first dose of study medication. 16. Known human immune deficiency virus (HIV) positive status, or a positive viral serology test. 17. Topical use of ibuprofen within 7 days before the first dose of study medication. 18. Strenuous physical exercise from 48 hours prior to first dose of study medication. 19. Those previously randomised into this study. 20. Those who are an employee at the study site. 21. Those who are a partner or first degree relative of the Investigator. 22. Participation in a New Chemical Entity clinical study within the previous 3 months or a marketed drug clinical study within the 30 days before the first dose of study medication. 23. Those unable in the opinion of the Investigator to comply fully with the study requirements.