Health, Fitness, and Quality of Life in Adolescent Girls With Turner Syndrome

University of Colorado, Denver21 enrolled

Overview

This study plans to learn more about how the energy system works in girls with Turner syndrome. This is important to know so that the investigators understand how Turner syndrome relates to diseases such as diabetes, extra weight gain, heart disease and liver disease, and how this impacts day to day life.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Turner Syndrome Turner Syndrome Mosaicism, 45, X/46, XX or XY Turner Syndrome Mosaicism 46,X,I(X)(Q10)/45,X Turner Syndrome Karyotype 46,X With Abnormal Sex Chromosome , Except I(Xq)

Interventions

No interventionOTHER

No intervention

Eligibility

Sex: FEMALEMin age: 12 YearsMax age: 21 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Female * Age 12-21 years * 45,XO karyotype in \>50% of cells tested with a diagnosis of Turner syndrome (TS) * Tanner stage 2-5 for breast development Exclusion Criteria: * Growth hormone treatment within the past 3 months * Diagnosis of type 1 or type 2 diabetes * Untreated hypertension with blood pressure \> 99%ile for sex, age and height or \>140/90 * Weight \> 300 lbs * Height \< 54" * Aortic sinus of Valsalva or ascending aorta z-score \> 2 * Other cognitive, psychiatric, or physical impairment resulting in inability to tolerate the study procedures, including vigorous exercise * Pregnancy

Locations (1)

Children's Hospital Colorado

Aurora, Colorado, United States

Outcomes

Primary Outcomes

Peak oxygen consumption

Peak oxygen consumption (VO2 peak) with a standard graded exercise (bicycle) test

Time frame: Baseline

Secondary Outcomes

Quality of Life Survey

Self and parent reported quality of life

Time frame: Baseline

Percent body fat

Body composition by dual-energy x-ray absorptiometry

Time frame: Baseline

Insulin resistance (IR)

Fasting insulin and glucose used to calculate homeostatic model assessment (HOMA)

Time frame: Baseline

Data from ClinicalTrials.gov

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