IRM Cognition in Patients With Head Trauma

University Hospital, Clermont-Ferrand20 enrolled

Overview

Longitudinal descriptive study of a cohort of twenty brain-damaged patients for a two years period.

The following data are collected in 3 months, 12 months then 24 months after the accident with followed data collection : * Clinical, neuropsychological assessments * Diffusion magnetic resonance imaging (MRI) for the reconstruction of anatomical pathways * Functional imaging data.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Brain-damaged Patients

Interventions

Cognitive rehabilitation programOTHER

Rehabilitation

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients, over the age of 18. * Mild traumatic brain injury (Initial Glasgow score between 9 and 12) * Severe brain injury (Initial Glasgow score between 3 and 8), * Diffuse axonal injury and/or focal lesions. Exclusion Criteria: * Patients with MRI contraindications, * Antecedents of brain lesions, * Important lesions of the lobes and cortex on cerebral CT, * Anoxic lesions related to cardiorespiratory arrest, * Must be able to perform neuropsychological tests, * Visual and auditory impairments. * Aphasia

Locations (1)

CHU Clermont-Ferrand

Clermont-Ferrand, Auvergne, France

Outcomes

Primary Outcomes

Changes in Baseline standardized volume of the white matter fascicles

determined on the "iplan" software. Baseline measured at 3 months after brain traumatic injury.

Time frame: at 3, 12 and 24 months

Secondary Outcomes

Measure of the volume of activations clusters

during functional MRI for attention, motor, working memory, language tasks.

Time frame: at 3, 12 and 24 months

Location of activation clusters

during functional MRI for attention, motor, working memory, language tasks.

Time frame: at 3, 12 and 24 months

Data from ClinicalTrials.gov

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