To assess the impact of daily awakening from sedation on the amount of vasoactive medication required in the ICU. The hypothesis of this proposal is that the amount of vasoactive drug required to maintain an adequate mean arterial blood pressure will be reduced during a daily awakening from sedation.
This observational study will compare mean arterial pressure and vasoactive drug dose recorded at two time points: 1. prior to awakening from sedation 2. during the awakening from sedation trial The vasoactive infusion will be titrated to a mean arterial pressure as determined by the medical team prior to study enrollment. Each enrolled patient will have measurements taken only on the first day of enrollment. Enrolled subjects will also have a delirium assessment using the CAM-ICU tool before the awakening from sedation trial and during the awakening from sedation trial.
Study Type
OBSERVATIONAL
Enrollment
800
vital signs and delirium assessment (CAM-ICU) at baseline then following routine sedation awakening trial. Patient will thus serve as their own control for these interventions
The University of Chicago Medical Center
Chicago, Illinois, United States
change in vasoactive drug dose
mcg/kg/min baseline dose and nadir dose
Time frame: baseline thru study completion on average < 4 hrs
change in mean arterial blood pressure
mm Hg
Time frame: baseline thru study completion on average <4 hrs
change in prevalence of ICU delirium
CAM ICU score
Time frame: baseline thru study completion on average <4hrs
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