Mechanisms of Anaphylaxis

N/AActive Not RecruitingNCT03182491

Haukeland University Hospital40 enrolled

Overview

The purpose of this study is to explore different mechanisms for anaphylaxis and find novel biomarkers for this hypersensitivity syndrome. The study participants are patients with anaphylaxis, patients with mild allergic reactions, and patients with febrile transfusion reactions. The investigators will also include a group of healthy controls.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Anaphylaxis Allergy Transfusion Reaction Febrile Transfusion Reaction

Interventions

Biomarkers (platelet activating factor [PAF], anaphylatoxins) and basophil activation test (BAT)DIAGNOSTIC_TEST

Analysis of biomarkers and basophil activation test

Eligibility

Sex: ALLMin age: 16 YearsMax age: 120 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: According to the specific cohort: 1. Diagnosis of anaphylaxis 2. Mild allergic reaction 3. Febrile transfusion reaction 4. Healthy, no known allergic disease Exclusion Criteria: Suspicion or diagnosed sepsis Children

Locations (1)

Haukeland University Hospital

Bergen, Norway

Outcomes

Primary Outcomes

Clarify mechanisms for anaphylaxis and establish biomarkers for this syndrome

Immunological/nonimmunological mechanism

Time frame: 2 days

Data from ClinicalTrials.gov

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