Detection of Integrin avb6 in IPF, PSC, and COVID19 Using PET/CT

1.0 Eligibility Criteria for IPF Patients 1.1 Inclusion Criteria The following inclusion criteria will be monitored: * Patient is \>/= 18 years old * Patient is capable of making an informed decision regarding his/her treatment * Patient diagnosed with IPF by a pulmonologist according to ATS guidelines * Patient has high-resolution CT with definite Usual Interstitial Pneumonia (UIP) pattern * Patient has PFT's within the last 12 months with: * FVC\<85% predicted * DLCO\<65% predicted * FEV1/FCV ratio \>70% * Patient is able to comply with study procedures * Scanning Option A OR * Scanning Option B 1.2 Exclusion Criteria The following exclusion criteria will be monitored: * Patient with a serious uncontrolled concurrent medical illness that would limit compliance with study requirements * Patient has a history of any clinically significant lung disease other than IPF as determined by a pulmonologist * Patient has had a lung infection of any kind in the last 3 months * Patient is pregnant or lactating 2.0 Eligibility Criteria for PSC Patients 2.1 Inclusion Criteria The following inclusion criteria will be monitored: * Patient is \>/= 18 years old * Patient is capable of making an informed decision regarding his/her treatment * Patient diagnosed with large duct PSC, based on an abnormal cholangiography as assessed by magnetic resonance cholangiopancreatography (MRCP), endoscopic retrograde cholangiopancreatography (ERCP), and/or percutaneous transhepatic cholangiopancreatography (PTC) in the context of cholestatic liver chemistry * Patient is able to comply with study procedures * Scanning Option C 2.2 Exclusion Criteria The following exclusion criteria will be monitored: * Patient with a serious uncontrolled concurrent medical illness that would limit compliance with study requirements * Patient has other causes of liver disease, including secondary sclerosing cholangitis or viral, metabolic, or alcoholic liver disease, as assessed clinically * Patient has a history of ascending cholangitis within 60 days of screening, as assessed clinically * Patient has history, current clinical or radiological suspicion, or diagnosis of cholangiocarcinoma, other hepatobiliary malignancy, colorectal cancer, or other abdominal malignancy at any time * Presence of a percutaneous drain or bile duct stent * Patient is pregnant or lactating 3.0 Eligibility Criteria for Healthy Controls 3.1 Inclusion Criteria The following inclusion criteria will be monitored: * Person is \>/= 45 years old * Person is capable of making an informed decision regarding his/her treatment * Person is able to comply with study procedures * Scanning Option A OR * Scanning Option B 3.2 Exclusion Criteria The following exclusion criteria will be monitored: * Person with a serious uncontrolled concurrent medical illness that would limit compliance with study requirements * Person has a history of any clinically significant lung disease other than IPF as determined by a pulmonologist * Person had lung infection of any kind in the last 3 months * Person is pregnant or lactating 4.0 Eligibility Criteria for COVID-19 patients 4.1 Inclusion Criteria The following inclusion criteria will be monitored: * Patient is \>/= 18 years old * Patient is capable of making an informed decision regarding his/her treatment * Patient with a history of SARS-CoV-2 (active or recovered) infection, based on positive RT-PCR testing * Recovered COVID-19 patient must show evidence of being non-infectious (per Stanford guideline): * Symptomatic, non-immunocompromised outpatients are considered COVID neg after 10 days or 3 days after symptoms resolve, whichever is longer. * Severely symptomatic or is immunocompromised outpatients are considered non-infectious after 20 days. * or RT-PCR negative x2, spaced \>24 hrs apart * Patient shows or has shown evidence of pulmonary opacities as visualized on chest radiograph or CT * Patient is able to comply with study procedures and infection control instructions * Recovered COVID 19 patients: Scanning Option A OR * Recovered COVID-19 patients: Scanning Option B * COVID-19 patients with active infection or no evidence of non-active infection: Scanning Option D 4.2 Exclusion Criteria The following exclusion criteria will be monitored: * Person with serious uncontrolled concurrent medical illness, such as severe hypoxia, that would limit compliance with study and infection control requirements * Person with pre-existing fibrosing lung disease (such as but not limited to IPF, NSIP, HP, and sarcoidosis prior to COVID-19 infection). * Person is pregnant or lactating