The purpose of this proof-of-concept controlled-feeding study is to determine whether patiromer (Veltassa®, Relypsa, Inc., Redwood City, CA) can be used to maintain normal serum potassium concentrations in chronic kidney disease (CKD) patients who are transitioned to a plant-rich diet.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
3
Patiromer dosing will be determined based on fasting potassium concentrations measured at the end of each week, factoring in both the absolute concentration, as well as the rate of change. The baseline dose of patiromer will correspond to the study by Weir et al. (2015); 8.4-g once per day for participants with a baseline serum potassium of greater than or equal to 5.1 mEq/L.
During the study, participants will be asked to consume only the foods provided in the research diet
NYU Langone Health
New York, New York, United States
Change in Fasting Serum Potassium Concentrations
Time frame: Baseline, Week 2
Change in Fasting Serum Potassium Concentrations
Time frame: Baseline, Week 4
Change in Systolic Blood Pressure (SBP)
Time frame: Baseline, Week 2
Change in Systolic Blood Pressure (SBP)
Time frame: Baseline, Week 4
Change in Diastolic Blood Pressure (DBP)
Time frame: Baseline, Week 2
Change in Diastolic Blood Pressure (DBP)
Time frame: Baseline, Week 4
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