This randomized, double-blind, placebo-controlled study aimed to evaluate the effect of ginseng(GINST) supplementation for 12 weeks on sperm motility.
This multicenter, randomized, double-blind, placebo-controlled clinical trial was aimed to evaluate of sperm motility improvement effect of fermented ginseng(GINST). Experimental arm and control arm were randomly assigned among the volunteers who met the inclusion criteria: men between the ages of 18 and 60 who had sperm motility of less than 32%. To experimental arm, capsules including 160mg of fermented ginseng(GINST) ingredients will be provided for 12 weeks. To control arm, capsules of the same shape and weight as GINST capsules will be provided. These capsules are made of a cellulose component. Primary outcome is sperm motility. Secondary outcome are \<Brief Male Sexual Function Inventory\> , \<Fatigue Severity Scale\>, and \<the Short Form (36) Health Survey\> measured at baseline and end of the trial.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
60
Intervention group should take fermented ginseng (GINST) capsule 3 times a day, 2 capsules at one time for 12 weeks
Control group should take placebo capsule 3 times a day, 2 capsules at one time for 12 weeks
Wonju Severance Christian Hospital
Wŏnju, Gangwondo, South Korea
RECRUITINGGil Hospital
Incheon, South Korea
RECRUITINGSeverance Hospital
Seoul, South Korea
RECRUITINGSperm motility
Sperm motility is evaluated by Computer-Aided Semen Analysis, or CASA. Sperm motility will be expressed as '% motile' , the percent of cells that are motile. According to WHO definition, asthenozoospermia is regarded as falling below 40% motility in this study.
Time frame: Change from baseline sperm motility at 12 weeks
Quality of life
Quality of life was evaluated by The Short Form (36) Health Survey(SF-36 questionnaire) at baseline and 12weeks after intervention
Time frame: Change from baseline quality of life at 12 weeks
Fatigue questionnaire
Fatigue was evaluated by Fatigue Severity Scale at baseline and 12weeks after intervention
Time frame: Change from baseline Fatigue Severity Scale at 12 weeks
Sexual function
Sexual function was evaluated by Brief Male Sexual Function Inventory (questionnaire) at baseline and 12weeks after intervention
Time frame: Change from baseline Sexual Function Inventory (questionnaire) at 12 weeks
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