Rationale: To identify the prevalence of Acute-on-chronic liver failure in Zagazig University Hospitals. The question of the research: How much the prevalence of Acute-on-chronic Liver Failure in Zagazig University Hospitals? The aim of the work: The aim of the study is to identify the presence of Acute-on-chronic Liver Failure in Zagazig University Hospitals Objectives: To estimate the prevalence of Acute-on-chronic Liver Failure in Zagazig University Hospitals. Subjects and Methods: I . Technical Design: * Site of the study: Gastroenterology and Hepatology Unit- Zagazig University Hospitals * Sample size: ''all patients admitted to Gastroenterology and Hepatology Unit with the criteria of ACLF according to EASL-AASLD from June 2017 to December 2017 were included in this study''. II . OPERATIONAL DESIGN: * Type of the study: a prospective study. * Full medical history - taking. * Full clinical examination. * Laboratory investigations including Routine laboratory investigation " CBC, Liver functions test, kidney functions test and prothrombin time " III. Administrative Design: * Approvals obtained for performing the study from the official or governmental department. * An ethical committee from the faculty of medicine and patients included in the study. Results: Collected data will be presented in tables and suitable graphs and analyzed according to standard statistical methods
Study Type
OBSERVATIONAL
Enrollment
300
Salem Mohamed
Zagazig, Sharqia Province, Egypt
improvement of the patients score according to SOFA score (AASLD and EASL guidelines)
follow up of participants until the patients recover
Time frame: 24 weeks from first recruiting
death of the patient
due to the severity of acute on chronic failure, the death of patients is expected
Time frame: 24 weeks from first recruiting
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