Noninvasive Positive Pressure Ventilation in Overlap Syndrome

Chinese Academy of Medical Sciences, Fuwai Hospital292 enrolled

Overview

Chronic obstructive pulmonary diseases (COPD) coexisting with obstructive sleep apnea is called overlap syndrome (OS). Patients with OS seem to have worse prognosis than patients with only one disorder. Noninvasive positive pressure ventilation is an efficient treatment in obstructive sleep apnea, but the effectiveness in improving outcomes of OS patients is still not fully investigated. The aim of this non-randomized concurrent control trial is to evaluate noninvasive positive pressure ventilation's effectiveness in OS patients.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

292

Conditions

COPD Sleep Apnea Syndromes Non-invasive Positive Pressure Ventilation

Interventions

Eligibility

Sex: ALLMin age: 40 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with COPD and sleep apnea dyspnea syndrome Exclusion Criteria: * patients with non-stable hemodynamics; * patients with limited life expectancy; * patients with other severe respiratory diseases; * patients with motor neuron diseases; * patients with contraindications for NIPPV

Outcomes

Primary Outcomes

COPD acute exacerbations

total times of COPD acute exacerbations

Time frame: 3 years

Secondary Outcomes

COPD assessment test (CAT) score

symptom score of COPD

Time frame: 3 years

modified British medical research council (mMRC) score

dyspnea score

Time frame: 3 years

all-cause mortality

survival rate in %

Time frame: 3 years

Noninvasive Positive Pressure Ventilation in Overlap Syndrome

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts