Pulmonary Vasculature and Right Heart Dysfunction in Chronic Obstructive Pulmonay Disease

Chinese Academy of Medical Sciences, Fuwai Hospital600 enrolled

Overview

The pulmonary vasculopathy and right heart dysfunction in COPD are drawing increasing attention these days. Recent researches show that pulmonary vasculopathy and right heart dysfunction relate to greater severity in COPD. Applying appropriate modalities for early detection of pulmonary vasculopathy and right heart dysfunction is of great importance. What's more, the interaction mechanism between pulmonary vasculature, right heart and COPD still needs to be further studied. The aim of our study is to develop an assessment system of pulmonary vasculopathy and right heart dysfunction in COPD patients and elucidate their impact on COPD course and outcome.

Study Type

OBSERVATIONAL

Enrollment

600

Conditions

COPD Pulmonary Vascular Disorder Right Ventricular Dysfunction

Eligibility

Sex: ALLMin age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * stable COPD patients Exclusion Criteria: * patents with other respiratory diseases and pulmonary hypertension other than group 3 PH; * psychopath, addict or patients not able to coordinate; * patients in pregnancy or breastfeeding; * patients with limited life expectancy; * patients with contraindiction for MRI or PET; * patients having cerebrovascular events in 3 months; * unstable COPD patients

Outcomes

Primary Outcomes

All-cause mortality

survival rate in %

Time frame: 3 years

Secondary Outcomes

COPD exacerbations

total times

Time frame: 3 year

GOLD degree

Ⅰ-Ⅳ according to the pulmonary function

Time frame: 3 year

NYHA degree

Ⅰ-Ⅳ according to the symptom

Time frame: 3 year

Pulmonary Vasculature and Right Heart Dysfunction in Chronic Obstructive Pulmonay Disease

Overview

Conditions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts