Silver Diamine Fluoride for Caries Prevention in Removable Partial Dentures Wearers

The University of Hong Kong196 enrolled

Overview

This study measures and compares the effect of silver diamine fluoride (SDF) on caries increment in removable partial denture wearers. Half of the participants will SDF and while the other half will receive placebo.

Removable partial dentures are commonly constructed to replace missing teeth. It is observed that removable partial denture wearers are susceptible to dental caries. The mode of action of silver diamine fluoride on caries prevention is dual: fluoride ions interact synergistically with silver to react with hydroxyapatite to form fluorapatite, and silver is bactericidal by reacting with the thiol groups of the amino and nucleic acids that halt the metabolic and reproductive functions of the cariogenic bacteria.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

196

Conditions

Dental Caries Dental Caries of Root Surface

Interventions

Silver Diamine FluorideDRUG

Silver diamine fluoride solution is applied to the dried and exposed coronal and root surfaces of all teeth by means of a disposable microbrush.

Distilled WaterDRUG

Distilled water is applied to the dried and exposed coronal and root surfaces of all teeth by means of a disposable microbrush.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who are wearing removable partial dentures constructed by staff or students at the Prince Philip Dental Hospital are recruited Exclusion Criteria: * If they have less than 4 teeth in any dental arch, have advanced periodontal disease in 2 or more sextants, have received therapeutic radiation of the head and neck region, have concurrent systemic illness that alters salivary flow, or have participated in a clinical trial within 6 months before the commencement of participation in this study.

Outcomes

Primary Outcomes

Caries increment

New and recurrent caries lesions are recorded according to the International Caries Detection and Assessment System (ICDAS). Molars and premolars are considered to have 5 coronal surfaces, whereas canines and incisors are considered to have 4. The cleaned and dried teeth are recorded as sound, sealed, restored, crowned, or missing. Each coronal tooth surface is classified using a 7-point ordinal scale ranging from sound to extensive cavitation using a WHO probe. The same procedure is repeated for all root surfaces. Coronal and root surface caries increments are calculated by comparing the baseline and follow-up observations for each tooth surface.

Time frame: 36 months

Secondary Outcomes

Prevalence of oral colonization of oral yeasts

The prevalence of oral yeast in oral rinse and dental plaque is counted. Prevalence is expressed as percentage of the participants.

Time frame: 36 months

Colonization of oral yeasts in oral rinse

The count of oral yeasts in oral rinse is recorded. The count of oral yeast in oral rinse is expressed as colony-forming unit (cfu)/ml.

Time frame: 36 months

Colonization of oral yeasts in dental plaque

The count of oral yeasts in dental plaque is recorded. The count of oral yeast in dental plaque is expressed as cfu/g.

Time frame: 36 months

Prevalence of oral colonization of Streptococcus mutans (S. mutans)

The prevalence S. mutans in stimulated whole saliva (SWS) and dental plaque is counted. Prevalence is expressed as percentage of the participants.

Time frame: 36 months

Colonization of S. mutans in saliva

The count of S. mutans in SWS is recorded. The count of S. mutans in SWS is expressed as cfu/ml.

Data from ClinicalTrials.gov

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