The Preventive Effects of Sub Hypnotic Dose of Propofol for Nausea and Vomiting Induced by Hemabate

West China Second University Hospital60 enrolled

Overview

This is a randomized, placebo-controlled trail, the objective of this study is observation the effect of sub hypnotic dose of propofol for prevention of nausea and vomiting induced by hemabate during spinal anesthesia for elective cesarean section. The primary outcome is the presence of post-delivery intra-operative nausea and vomiting in parturients. The patients demographic characteristics, blood pressure, sensory block level, and the medications will be collected.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Nausea and Vomiting

Interventions

PropofolDRUG

first dose 0.3mg/Kg propofol, then 1mg/Kg/hr micro-pump

Normal salineDRUG

first dose 0.03ml/Kg placebo saline, then 0.1ml/Kg/hr micro-pump

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 20-40 years; * American Standards Association status I-II. Exclusion Criteria: * Patients with allergy or hypersensitivity to propofol, lipid emulsion, or granisetron; * History of nausea or vomiting within 24h before cesarean delivery; * History of gastrointestinal or psychiatric disease, motion sickness, smoking, postoperative nausea and vomiting; * Morbid obesity; * Consumption of drugs such as opioids, antiemetics , H2 antagonists, phenothiazines and/or corticosteroids within 24h before the study period; * Any chronic medical or surgical disorders complicating the pregnancy; * Conditions contraindicating regional anesthesia.

Locations (1)

West China Second University Hospital

Chengdu, Sichuan, China

Outcomes

Primary Outcomes

The presence of nausea and vomiting

the patients were not asked directly about nausea during the course of the surgery, but its incidence was recorded when spontaneously reported vomiting was recorded as observed by investigator

Time frame: 24 hours

Data from ClinicalTrials.gov

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