Role of Stem Cell Therapy in Interstitial Pulmonary Fibrosis

Inclusion Criteria: * Age 18 to 75 years (both inclusive) * high-resolution computed tomography (HRCT) scan that is very suggestive or consistent with a probable diagnosis of usual interstitial pneumonia. * Bronchoalveolar lavage must be performed at any time before inclusion and must have failed to show features supporting alternative diagnoses. * The duration of the disease should be more than three months, and bibasilar inspiratory crackles should be present. * dyspnea score of at least 2 on a scale of 0 (minimum) to 10 (maximum). * FVC \> 50% of the predicted normal value and DLco \> 35% of the predicted value. * Patients under treatment with n-acetylcysteine or pirfenidone should discontinue drug and enter a wash-out period for at least 6 weeks prior study enrolment. Exclusion Criteria: * FVC \< 50% predicted normal value and DLCO \< 35%predicted normal value. * lung cancer or with an evidence of active malignancyfor at least 5 years. * uncontrolled heart failure. * renal failure * hepatic failure, * neurological abnormalities including stroke and myasthenia Gravis * Anti-coagulants therapy. * Active infections.