A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GDC-0853 in Healthy Japanese and Caucasian Participants

Inclusion Criteria: * Japanese subjects must have both Japanese parents and all grandparents who were born in a Japanese country of origin * Caucasian subjects must have 4 Caucasian grandparents (Hispanics of white race can be considered Caucasians) * Within body mass index range of 18 to 31 kilograms per square meter, inclusive * Females will be non-pregnant, non-lactating, and either postmenopausal or surgically sterile * Males will either be sterile or agree to use an approved method of contraception Exclusion Criteria: * Significant history or clinical manifestation of any significant metabolic, allergic/immunologic/immunodeficiency, dermatological, hepatic, renal, hematological, pulmonary, cardiovascular, gastrointestinal, neurological, or psychiatric disorder (as determined by the investigator) * History of significant hypersensitivity, intolerance, or allergy to any drug compound, food, or other substance, unless approved by the investigator * Participation in any other investigational study drug trial in which receipt of any investigational study drug occurred within 30 days or 5 half-lives, whichever is longer, prior to check in * History of malignancy, except for appropriately treated carcinoma in situ of the cervix or non-melanoma skin carcinoma with 3-year disease-free follow up * Any acute or chronic condition or any other reason that, in the opinion of the investigator, would limit the participant's ability to complete and/or participate in this clinical study