Nonalcoholic steatohepatitis (NASH) is now recognised as an increasing clinical problem in children. Steatosis without significant liver cell injury or fibrosis is the most common form of nonalcoholic fatty liver disease (NAFLD) in both adults and children. Studies in the adult population have variably suggested that steatosis is a benign nonprogressive condition and NASH is recognised as a potentially serious condition with significantly risk of morbidity and mortality. A growing body of evidence suggests that children with NASH frequently show histopathological features that differ from those of adults. The prevalence of this pattern in a wide range of paediatric cases as well as other histopathological lesions and their relevance and prognostic significance in children with NAFLD remains to be determined. Thus the investigators would like to conduct a study of biopsies and clinical information to document the histological features of paediatric NAFLD, to explore the natural history of paediatric NAFLD, and to determine the frequency and prognostic value of these features.
Study Type
OBSERVATIONAL
Enrollment
400
There will be no specific intervention to these paediatric NASH patient
Children's Liver Disease Center, 302 Hospital
Beijing, China
RECRUITINGLiver related death
Whether the patients die from liver-related causes
Time frame: Through study completion, an average of 1 year
Complications of cirrhosis
Whether the complication of cirrhosis i.e. ascites, hepatic encephalopathy, variceal bleeding occur during the follow-up
Time frame: Through study completion, an average of 1 year
Liver biopsy
Time frame: Through study completion, an average of 2 year
Liver transplant
Whether the patients have liver transplant during the follow-up
Time frame: Through study completion, an average of 1 year
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