The purpose of this research study is to compare the current standard of care for prophylactic Cefazolin administered every 3 hours intravenously with continuous infusion of Cefazolin during pediatric spinal surgery.
Determine the skeletal muscle and adipose tissue disposition of prophylactic Cefazolin using microdialysis sampling in a cohort of patients diagnosed with idiopathic scoliosis undergoing posterior spinal fusion (PSF) for administration of Cefazolin by either continuous infusion or intermittent bolus.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
12
Mode of Cefazolin administration will be a intermittent bolus
Mode of Cefazolin administration will be a continuous drip
Two dialysis probes will be inserted into a paraspinal muscle
University of Florida
Gainesville, Florida, United States
Unbound Cefazolin Concentration in Skeletal Muscle
First regimen and second regimen difference between unbound Cefazolin concentrations in the interstitial fluid of skeletal muscle
Time frame: Changes from baseline (pre-op) up to end of surgical procedure
Unbound Cefazolin in Adipose Tissue
First regimen and second regimen difference between unbound Cefazolin concentrations in the interstitial fluid of adipose tissue
Time frame: Changes from baseline (pre-op) up to end of surgical procedure
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Two dialysis probes will be inserted into a paraspinal subcutaneous region