Motivation and Methylphenidate

Early Phase 1CompletedNCT03190681

Institut National de la Santé Et de la Recherche Médicale, France35 enrolled

Overview

The purpose of this study is to evaluate the impact of methylphenidate, a mixed dopaminergic and noradrenergic agent, onto the different components of motivation: decision-making, effort allocation and instrumental learning.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Motivation Apathy Impulsive Behavior

Interventions

Ritalin 10Mg TabletDRUG

oral ingestion of 3 tablets in a single-dose

Placebo Oral TabletDRUG

oral ingestion of 3 tablets in a single-dose

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * weight\>= 50kg and \<=90kg * free and informed consent * social security affiliation * no chronic illness * no previous participation to a protocol wth similar tasks * no special legal status (guardianship,trusteeship) * no personnal or familial neurologic or psychiatric background * no contraceptive device for a reproductive woman Exclusion Criteria: * inability to squeeze a handgrip * smoking * psychoactive substance consumption less than 3 weeks ago * pregnant or breastfeeding woman * hypersensitivity to methylphenidate * hyperthyroidism * cardiovascular or cerebrovascular disease * respiratory, hepatic or renal failure * glaucoma * pheochromocytoma * gluten intolerance or hypersensitivity * galactosemia, glucose malabsorption syndrome, lactase deficit * countraindicated meds (IMAO, IMAO-A, orhtosympathomimetics, alcaloids, linezolin, enzymatic inducers, psycho-active drugs)

Locations (1)

Centre d'investigation clinique, Institut du Cerveau et de la Moelle

Paris, France

Outcomes

Primary Outcomes

coefficient of sensitivity to reward

Parameter characterizing the influence of reward expectation/experience onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task).

Time frame: two hours after administration

Secondary Outcomes

coefficient of sensitivity to effort

Parameter characterizing the influence of effort expectation/experience onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task).

Time frame: two hours after administration

coefficient of sensitivity to punishment

Parameter characterizing the influence of punishment expectation/experience onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task).

Time frame: two hours after administration

coefficient of sensitivity to delay

Parameter characterizing the influence of delay expectation onto behavior for each individual. This parameter is estimated through the fit of computational models to behaviors recorded in a battery of motivational tasks (choice task, effort task, Learning task).

Time frame: two hours after administration

Data from ClinicalTrials.gov

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