The Role of Expectations in the Pharmacological Treatment of Depression - An Experimental Investigation

N/ACompletedNCT03190772

Philipps University Marburg94 enrolled

Overview

The study aimes at identifying whether positive expectations have an impact on the way depressive participants experience emotions in the form of sadness.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

Conditions

Major Depressive Episode

Interventions

Placebo nasal sprayOTHER

The placebo nasal spray consists of sesame oil and does not contain any active drug.

Film sequenceOTHER

All groups watch the film sequence that is supposed to induce sadness.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * major depression (mild to moderate) * fluent in German language Exclusion Criteria: * bipolar disorder, psychotic disorder, substance dependence * cardiovascular disease, severe kidney or liver disease, epilepsy * change of psychotropic medication intake within the last four weeks * allergic to capsaicin * allergic to sesame oil * students in medicine, pharmacy, or psychology in their third year or older * completed studies in medicine, pharmacy or psychology

Locations (2)

Justus Liebig University Gießen

Giessen, Hesse, Germany

Philipps University Marburg

Marburg, Hesse, Germany

Outcomes

Primary Outcomes

Sadness

Items of PANAS-X

Time frame: Directly after watching the film sequence, no follow-up assessments

Data from ClinicalTrials.gov

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