In Vivo Predictive Dissolution 1

N/ACompletedNCT03191045

University of Nottingham20 enrolled

Overview

This study will: 1. validate MRI motility method with concomitant perfused manometry method in healthy adult participants. 2. measure exploratory endpoints of interest including GI fluid volumes in 21 adult healthy volunteers studied twice.

The gastrointestinal (GI) environment where drug products dissolve has not been studied in detail due to limitations, especially invasiveness of existing techniques. Hence little in vivo data on GI fluids and motility is available to improve relevance of predictive dissolution models and bench dissolution techniques. Recent advances in magnetic resonance imaging (MRI) methods could provide novel data and insights. On-going studies at the University of Michigan and at the University of Nottingham, using advanced, validated, quantitative MRI techniques have already shown that GI fluid (water) volumes can be measured. The classical method for measuring GI motility is via a manometric method involving intubation, but it is possible to measure GI motility with MRI. Based on our MRI motility pilot data and on the literature available, this study aims to test the main hypotheses that in healthy adult participants the new MRI method has the potential to replace current manometric study protocols and will allow a simultaneous measurement of gastrointestinal motility and fluid volumes in the gut during the fasted state. This will establish a solid and unprecedented base of in vivo results upon which to base advances in oral pharmaceutical product science. For this initial study, the study objectives are therefore: 1. To validate the MRI motility method with concomitant perfused manometry method in healthy adult participants. 2. To measure exploratory endpoints of interest including GI fluid volumes. Twenty one adult healthy volunteers will participate in this replicated study. We will pass a thin perfused manometry tube via the nose into the gut of the participants and then take MRI images of abdominal areas while bowel motility is being measured via a tube manometric method to see how they compare. We will be able also to measure the volume of fluids in the gut.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Healthy

Interventions

MRI and concomitant perfused manometry of bowel motilityDIAGNOSTIC_TEST

We will carry out serial cine MRI of the bowel. At the same time we will record perfused manometry readings of the bowel in healthy adult participants.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Aged 18-60 * Healthy * Male or female * Able to give informed written consent and willing to comply with required study procedures Exclusion Criteria: * Any history of serious, unstable medical condition, unstable/uncontrolled diabetes mellitus, and/ or major psychiatric diagnosis such as attention deficit hyperactivity disorder, obsessive compulsive disorder, panic attacks and generalized anxiety disorder. * Any reported history of gastrointestinal disease * Any significant respiratory disease such as asthma * Any conditions requiring daily intake of any prescription and/or over-the-counter medications * Any reported history of surgery that could affect gastrointestinal function (e.g. colectomy, small bowel resection) * Reported alcohol dependence * Abnormal screening procedures and laboratory results that are clinically significant in the opinion of the study medically qualified researcher * Pregnancy * Contraindications for MRI scanning i.e. metallic implants, pacemakers, history of metallic foreign body in eye(s) and penetrating eye injury * Inability to lie flat * Weight exceeding scanner limits of 120kg * Poor understanding of English language * Any conditions causing fidgeting * Claustrophobia * Participation of any medical trials for the past 3 months * Judgement by the study medically qualified researcher that the candidate will be unable to comply with the full study protocol e.g. severe chronic obstructive pulmonary disease

Locations (1)

Nottingham Digestive Diseases Centre

Nottingham, United Kingdom

Outcomes

Primary Outcomes

Stomach MRI motility

Area under the curve (AUC) of the stomach motility contractions (in mm×second) measured by MRI.

Time frame: Over set time bins and recorded for up to 4 hours

Secondary Outcomes

Stomach perfused manometry motility

Area under the curve (AUC) of the stomach motility contractions (in mmHg×second) measured by perfused manometry

Time frame: Over set time bins and recorded for up to 4 hours

Data from ClinicalTrials.gov

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