Interaction Research on Cognitive Impairment and Emotional Disorder in End-stage Renal Disease

N/AUnknownNCT03191409

First Affiliated Hospital Xi'an Jiaotong University50 enrolled

Overview

End stage renal disease (ESRD) is the last stage (stage 5) of chronic kidney disease (CKD). Abnormalities of cognitive function and high levels of depression or anxiety incidence are characteristic of hemodialysis patients. In this research project, the investigators subject in ESRD patients starting hemodialysis as the carrier. Based on the longitudinal research design, using multimodal neuroimaging data，combining with the interact relationship between changes of brain morphology, the dysfunction of resting-state and-task state with cognitive impairment and abnormal emotions.Establish brain structure-function change model associated with dialysis progression, Explore imaging markers of central and disease development characteristics in ESRD patients. the investigators attempt to clarify the core mechanism of kidney-brain axis damage, thus provide evidence for early cognitive-behavioral therapy to CKD patient.

Study Type

OBSERVATIONAL

Enrollment

Conditions

End-stage Kidney Disease Brain Damage

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age 18-50 years; 2. ESRD patients who will start hemodialysis 3. High quality MRI scan; 4. dextromanual Exclusion Criteria: 1. Diabetes,Brain tumor,brain trauma 2. Neuropsychiatric disease

Locations (2)

First Affiliated Hospital of Xi'an Jiaotong University

Xi'an, Shaanxi, China

RECRUITING

First affiliated hospital of Xi'an Jiaotong University

Xi'an, Shaanxi, China

RECRUITING

Outcomes

Primary Outcomes

change in cognitive function

Cognitive testing will be performed for assessment

Time frame: Change from Baseline to 3 Months after dialysis

Secondary Outcomes

Change in brain MRI

Brain MRI will be performed before dialysis initiation and dialysis more than 3 months