Skin IaM: An Exploratory Clinical Trial to Evaluate Changes in Skin Appearance, Colour, and/or Texture Following the Induction of a Local Inflammatory Skin Response

Inclusion Criteria: * Male aged \>25- \<40 years. * Healthy, non-smoker. * In the opinion of the investigator, the subject will be able to comply with the requirements of the protocol, including ability to present for all required visits. * Subject is capable of understanding and signing an informed consent form. * White origin (limit Skin Fitzpatrick I to III). Exclusion Criteria: * Male aged \< 25 years or \>40 years. * Female of any age. * Tattoos on or within 5 cm of the area to be assessed. * Scars on or with 5 cm of the area to be assessed. * Current, active inflammatory skin disease, or past history of any inflammatory skin disease (other than acne) such as psoriasis, atopic dermatitis. * Suffered from any significant allergies (i.e. food, environmental, contact). * Subjects who are immunocompromised (i.e. HIV positive, Hepatitis C, transplant, etc.), based on clinical history. * Subjects who currently have an activated immune system (e.g from current infection or recent vaccination). * Subjects who have a history of chronic disease such as diabetes. * Use of investigational therapy in the preceding month prior to screening visit. * Use of G-CSF, GM-CSF, IL-2, IFNs, erythropoietin, systemic or inhaled steroids within one month of the screening visit. * Use of oral analgesics/anti-inflammatories (e.g. paracetamol, ibuprofen, aspirin, codeine) or topical anti-inflammatories (e.g., ibuprofen) within 5 days of the screening visit. * Concurrent disease or conditions that may present a risk to the subjects.