AMBULATE: Cardiva Mid-Bore VVCS vs. Manual Compression for Multiple Femoral Venous Access Sites, 6 - 12F ID

Inclusion Criteria: * Acceptable candidate for an elective, non-emergent catheter-based procedure via the common femoral vein(s) using a 6 to 12 Fr inner diameter introducer sheath, with a minimum of 3 and maximum of 4 femoral venous access sites, and a maximum of 2 access sites/leg * Anticipated prolonged bedrest (5 hours or more) and / or overnight stay Exclusion Criteria: * Active systemic or cutaneous infection, or inflammation in vicinity of the groin * Pre-existing immunodeficiency disorder or chronic use of high dose systemic steroids * Know history of bleeding diathesis, coagulopathy, hypercoagulability or platelet count \< 100,000 cells/mm3 * Severe co-existing morbidities with life expectancy less than 12 months * Femoral arteriotomy or femoral venotomy in \< 10 days, or with any known vascular complications or residual hematoma, or with use of an intravascular closure device w/in previous 30 days * Planned femoral venous or arterial access within next 30 days * History of DVT, pulmonary embolism or thrombophlebitis * Significant anemia or renal insufficiency * BMI \> 45 kg/m2 or \< 20 kg/m2 * Unable to routinely walk at least 20 ft. without assistance * LMWH within 8 hours before or after procedure * Access site-specific eligibility criteria to exclude problems with gaining access or location of sheath; \< 6 Fr or \> 12 Fr inner diameter sheath use; obvious bleeding complications or tissue tract estimated to be \< 2.5 cm deep