This is a single-center prospective randomized control trial (RCT) to determine whether the continuous monitoring of the plethysmographic variability index (PVI) during low-risk surgeries, can be used to optimize the intraoperative fluid administration. Low-risk patients that attend our day surgery unit, and who will be operated under general anesthesia, will be randomized to either a liberal fluid group, a restrictive fluid group or a dynamic monitoring group (PVI-directed). The amount of fluid infused together with the time to discharge, will be assessed in each participant during the postoperative period along with additional secondary outcomes.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
243
Only ringer lactate (RL solution will be used). 1. Fluid loading at induction with 500 ml of ringer lactate solution will be given to some groups. 2. Base infusion rate varies according to group. 3. Fluid challenges - infusion of 250 ml over 5 min, a hemodynamic parameter specific to each group will be monitored for 10 min after the end of infusion to look for changes. Patients who do not respond to four (4) fluid challenges (volume infused 1000 ml) will be excluded.
Policlinica Metropolitana
Caracas, Miranda, Venezuela
Total volume of fluid infused intraoperatively
Total volume of ringer lactate solution infused intraoperatively to participants (ml).
Time frame: 0 min after extubation
Time to discharge
Time in hours (h) from anesthesia reversal to fulfillment of patient discharge criteria. Patients will be assessed by an attending nurse every 30 min to assess the fulfillment of these criteria.
Time frame: 240 min after extubation (discharge)
Significant postoperative nausea and vomiting (PONV)
Presence of significant PONV as determined by a score ≥5 on the scale proposed by Myles SA et al. (BJA 2012)
Time frame: 240 min after extubation (discharge)
Postoperative dizziness
Presence of patient self-reported dizziness in the post-operative period.
Time frame: 30 min after reversal
Postoperative fatigue
Presence of patient self-reported fatigue after surgery.
Time frame: 30 min after reversal
Postoperative thirst
Presence of patient self-reported thirst after surgery
Time frame: 30 min after reversal
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