Fructose Extra-splanchnic Metabolism and Its Effects on Systemic Flux of Substrates (FruPP)

N/ACompletedNCT03195062

University of Lausanne9 enrolled

Overview

In parallel to the dramatic rise in metabolic diseases and diabetes observed over the past fifty years, the generalization of added sugar in processed food led to a marked increase in fructose consumption in almost all countries, and epidemiological studies demonstrated that the consumption of sugar-sweetened beverage (containing at least 50% of fructose) is associated with the development of diabetes, hepatic steatosis, dyslipidemia and obesity. The objective of the study is to measure the amount of fructose that escape first-pass hepatic extraction after oral ingestion (fructose+glucose), and gain insights into its metabolic fates with the use of tracers.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Test Meal

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Aged from 18 to 40 years * Body Mass Index of 18.5 to 25 kg/m² * Sex male of female Exclusion Criteria: * Fructose intolerance * Antidiabetic and hypolipemic drugs * Alcohol consumption \>10g/day * Severe eating disorders * Severe psychological problems * Vegetarian diet or other specific diet * Consumption of illicit substances * Pregnancy * Weight gain or weight loss \> 3 kg in the last 3 months

Outcomes

Primary Outcomes

Measurement of the amount of fructose that escape first-pass hepatic extraction after oral ingestion.

Calculation with 13C fructose enrichment in blood samples at T0; 30; 60; 90; 120; 150; 180; 210 and 240 min.

Time frame: The quantity of 13C fructose will be calculated, during the post prandial period, until 240 min.