The purpose of this study is to assess the safety and efficacy of low dosage of Terazosin in Carotid Artery Stenting
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
160
TZ 0.5mg once a day for 3-7 days before carotid artery stenting to 30 days later.
Carotid artery stenting is an alternative treatment of carotid artery stenosis, which would be performed by experienced neuroradiologist according to the latest guideline from American Heart Association and American Stroke Association.
Beijing Anzhen Hospital
Beijing, Beijing Municipality, China
RECRUITINGThe Luhe Teaching Hospital of the Capital Medical University
Beijing, Beijing Municipality, China
RECRUITINGParticipants who got New DWI Lesions (MRI)
Patients who got new ischemic lesions as defined by DWI MRI within 48 hours after carotid artery stenting
Time frame: Within 48 hours after carotid artery stenting
Number of New DWI Lesions (MRI)
Number of new ischemic lesions as defined by DWI MRI within 48 hours after carotid artery stenting
Time frame: Within 48 hours after carotid artery stenting
Volume of New DWI Lesions (MRI)
Volume of new ischemic lesions as defined by DWI MRI within 48 hours after carotid artery stenting
Time frame: Within 48 hours after carotid artery stenting
Number of patients with New DWI Lesions (MRI) diameter greater than 5mm
Patients who got new ischemic lesions diameter greater than 5mm as defined by DWI MRI within 48 hours carotid artery stenting
Time frame: Within 48 hours after carotid artery stenting
Number of Patients with Cerebrovascular Events, Cardiovascular Events or Death.
Cerebrovascular events included ischemic stroke, transient ischemic attack (TIA), cerebral hemorrhage and hyperperfusion syndrome. Cardiovascular events included angina and myocardial infarction. Death included any reason caused death.
Time frame: From baseline to 30 days after treatment
Laboratory Examination
Laboratory Examination before and post-treatment
Time frame: Before and 24 hours after carotid artery stenting
Number of Patients underwent hypertensive treatment due to post-procedure hypotention
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Number of Patients underwent hypertensive treatment due to post-procedure hypotention
Time frame: 0-7 days or discharge which comes early
Number of Patients with Any Side Events
Any side events caused by TZ, regular treatment or CAS
Time frame: From baseline to 30 days after treatment
Mortality
Any cause of death
Time frame: From baseline to 30 days after treatment