Pulmonary Hypertension (PH) is a severe disease with a bad prognosis. However, thanks to extensive research in this field, there are more and better treatment options that allow patients to participate in recreational activities at moderate altitude or bring up the question of air-travel. Still very few is known about the effects hypoxic conditions have on PH patients. The aim of this study is to investigate the effects of hypoxia in comparison to normoxia and hyperoxia on pulmonary hemodynamics in patients with pulmonary hypertension during routine right heart catheterisation. We aim to get insight into the pathophysiology of pulmonary hemodynamics under hypoxic conditions in comparison to normoxia and hyperoxia in patients with pulmonary arterial and chronic thromboembolic pulmonary hypertension compared with control patients, that are scheduled for right heart catheterisation due to dyspnea but have no PH.
Study Type
OBSERVATIONAL
Enrollment
44
10 minutes of breathing a gas mixture with FiO2 0.16 via a tight fitting mask. After 10 minutes of breathing ambient air (normoxia), patients were exposed to hyperoxia (FiO2 1.0) for 10 minutes.
UniversityHospital Zurich, Department of Pulmonology
Zurich, Switzerland
Change of pulmonary vascular resistance during hypoxia in comparison to normoxia and hyperoxia
Time frame: Day 1
change of mean pulmonary artery pressure under hyperoxia in comparison to normoxia and hyperoxia
Time frame: Day 1
change of the cardiac output under hyperoxia in comparison to normoxia and hyperoxia
Time frame: Day 1
change of the partial pressure of carbon dioxide under hyperoxia in comparison to normoxia and hyperoxia
Time frame: Day 1
change of the partial pressure of oxygen under hyperoxia in comparison to normoxia and hyperoxia
Time frame: Day 1
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