Association Between Insulin Resistance and Beta Cell Function With HbA1C in Diabetics

Overview

Progression of T2DM is widely accepted to be contributed by two main components: beta cell function deterioration where insulin secretion is impaired and insulin resistance where insulin physiological response is reduced. Insulin resistance and beta cell function will be estimated through a mathematical model, homeostasis model assessment. Fasting insulin and C-peptide will be measured using liquid chromatography tandem mass spectrometry. Insulin resistance and beta cell function is then compared with the glycaemic control, HbA1C.

Primary objective • To investigate the association between the estimation of insulin resistance and beta cell function through homeostasis model assessment with HbA1C among oral anti-diabetics treatment non-responder. Secondary Objectives * To compare the insulin resistance and beta cell function between the OAD treatment responders (negative control) and non-responders * To investigate the relationship between plasma level of metformin and gliclazide with the estimation of beta cell function and insulin resistance * To identify the proportion of patients with high insulin resistance and proportion of patients with low beta cell function * To identify difference in insulin resistance and beta cell function of different ethnic groups in Sarawak * To compare insulin resistance with cardiovascular disease risk using Framingham Risk Score and ASCVD risk estimation

Conditions

Interventions

Eligibility

Locations (1)

Outcomes