The purpose of this study is to assess the pharmacodynamics of Prednisolone in healthy male subjects
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
24
Specified dose on specified days
Specified dose on dose on specified days
Ppd Development
Austin, Texas, United States
Local Institution
Austin, Texas, United States
Interleukin 1 beta
As measured by flow cytometry
Time frame: Up to 32 days
Tumor necrosis factor-alpha
As measured by flow cytometry
Time frame: Up to 32 days
Receptor activator of nuclear factor-kB (RANK)
As measured by flow cytometry
Time frame: Up to 32 days
Receptor activator of nuclear factor-kB ligand (RANKL)
As measured by flow cytometry
Time frame: Up to 32 days
Osteoprotegrin (OPG)
As measured by flow cytometry
Time frame: Up to 32 days
Lipopolysaccharide Induced Cytokine Production
As measured by blood concentration
Time frame: Up to 32 days
Cell Populations
As measured by flow cytometry
Time frame: Up to 32 days
Oral glucose tolerance test
Assessed by central labortatory
Time frame: Up to 32 days
Cortisol
As measured by the level of the hormone cortisol in the blood
Time frame: Up to 32 days
Adrenocorticotropic hormone
As measured by the level of the hormone in the blood
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Time frame: Up to 32 days
Osteocalcin
As measured by blood concentration
Time frame: Up to 32 days
N-terminal Pro-Collagen Peptide (PINP)
As measured by blood concentration
Time frame: Up to 32 days
Propetide type I C-term Pro-collagen Peptide (CICP)
As measured by blood concentration
Time frame: Up to 32 days
Bone-specific alkaline phosphatase
As measured by blood concentration
Time frame: Up to 32 days
Urinary deoxypyridinoline
As measured by urine concentration
Time frame: Up to 32 days
C Telopeptide of Collagen Type II (CTX-II)
As measured by urine concentration
Time frame: Up to 32 days
Calcium
As measured by urine concentration
Time frame: Up to 32 days
Creatinine
As measured by urine concentration
Time frame: Up to 32 days