The study wants to define the maximum tolerated dose (MTD), safety and efficacy of a short course radiation treatment in patients with symptomatic advanced head and neck cancer.
The study wants to define the maximum tolerated dose (MTD) of a conformal short course accelerated radiation therapy delivered in twice daily fractions and 2 consecutive days, and the feasibility of this fractionation in term of safety and efficacy for symptomatic palliation of metastatic or locally advanced head and neck cancer.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
48
An accelerated hypo-fractionation radiotherapy is delivered for palliation in patients with metastatic or locally advanced head and neck cancer.
Maximum tolerated dose
The maximum tolerated dose is defined as the dose level below the highest administered dose associated with dose limiting toxicity (DLT) in at least one third of patients
Time frame: 1 year
Acute toxicity
Acute toxicity after treatment is evaluated with CTCAE scale
Time frame: 1 year
Quality of life
Quality of life after the treatment is evaluated according to CLAS scale
Time frame: 1 year
Pain relief
Pain after the therapy is evaluated with the visual analogic scale
Time frame: 1 year
Late toxicity
Late toxicity after the treatment is evaluated with EORTC-RTOG scale
Time frame: 1 year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.