Older studies in animals and humans have shown cancer responses to very low doses of whole-body or hemi-body radiation. To study the effects of low doses of radiation in patients with recurrent prostate cancer, investigators will enroll up to 21 patients for 10 fractions of low dose radiation, delivered over 5 weeks. Participants will be followed on study for 12 months, capturing PSA, CBC, QoL and blood samples for immunological analysis.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
21
Patients will receive 10 fractions of very low dose hemi-body radiation, delivered, twice per week, over five weeks
Hamilton Health Sciences
Hamilton, Ontario, Canada
PSA response
Proportion of patients with a reduction of PSA levels by at least 50%
Time frame: Within 12 months of study treatment
Immunological changes
Levels of CD8+ and CD16+ cells, cytokine levels
Time frame: Within 12 months of study treatment
Adverse Events
NCI-CTCAE
Time frame: Within 12 months of study treatment
Quality of Life
SF-36
Time frame: Within 12 months of study treatment
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