Efficacy and Safety of DF289 Plus DF277 Otic Solution in the Treatment of Acute Otitis Externa

Inclusion Criteria: * Uncomplicated AOE of less tan 21 days, defined as a total symptom score of at least 2 for otalgia, 2 for edema and 1 for otorrhea * Brighton Grading of II or III * Culture-based diagnosis of acute bacterial otitis externa * Willingness to refrain from swimming through end of the study Exclusion Criteria: * Previous episode of AOE within 4 weeks prior to enrollment, or 2 or more episodes of AOE within 6 months prior to the enrollment. * Tympanic membrane perforation * Any condition or situation likely to cause the patient to be unable or unwilling to comply with study treatment or attend all study visits * Any condition in the patient or parent/guardian that, in the judgment of the principal investigator, could compromise patient safety, limit the patient's ability to complete the study, and/or compromise the objectives of the study